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Related Experiment Video

Updated: Jun 16, 2025

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

A Fluorescence-based Method to Study Bacterial Gene Regulation in Infected Tissues

Published on: February 19, 2019

Control of morphogenesis during the Staphylococcus aureus cell cycle.

Mariana Tinajero-Trejo^1,2, Matthew Aindow^1,2, Laia Pasquina-Lemonche^1,2

¹School of Biosciences, University of Sheffield, Sheffield, UK.

Science Advances

|April 11, 2025

Summary

DivIB and FtsL coordinate bacterial cell division by regulating peptidoglycan synthesis at the septum. This study reveals their roles in divisome assembly and cell wall remodeling in Staphylococcus aureus.

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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

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Published on: January 17, 2025

Area of Science:

Microbiology
Cell Biology
Biochemistry

Background:

Bacterial cell division is a complex process involving the divisome, a protein complex controlling cell morphogenesis.
The precise mechanisms regulating septal progression and cell wall synthesis during division are not fully understood.

Purpose of the Study:

To investigate the roles of DivIB, DivIC, and FtsL in coordinating bacterial cell division.
To elucidate the mechanisms by which these proteins regulate peptidoglycan synthesis and divisome assembly.

Main Methods:

Analysis of conditional mutants for genes encoding DivIB, DivIC, and FtsL in Staphylococcus aureus.
Investigating the localization of divisome components and peptidoglycan synthesis dynamics.

Main Results:

DivIB and FtsL exhibit independent, hierarchical roles in coordinating peptidoglycan synthesis.
These proteins are essential for the localization of downstream divisome components.
They regulate peptidoglycan synthesis by promoting septum production and inhibiting peripheral synthesis.

Conclusions:

A model for cell division coordination in Staphylococcus aureus was developed.
This research provides a framework for understanding protein function integration with cell wall dynamics in bacteria.