Nanomaterials as novel matrices to improve biomedical applications of MALDI-TOF/MS
Zhiyi Wang1, Yuanting Tang1, Ying Zhang1
1College of Phamaceutical Science, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China.
Abstract:
With the rapid development of biomedical technology, there is an increasing demand for accurate analysis of biomolecules and their interactions. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a novel soft ionization biomass spectrometry technology that can accurately assess the molecular weight of samples quickly and sensitively, and it plays an important role in the analysis and detection of large molecule substances, drug research, and life sciences. In recent years, due to the outstanding performance of nanomaterials, they have been widely used as matrices in drug metabolism research and cancer detection. This paper aims to review the latest research progress of nanomaterials as new matrices for MALDI-TOF MS in enhancing biomedical analysis, discus its value and limitations, and look forward to its future research direction.
More Related Videos
09:49Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Published on: November 18, 2022
07:49Matrix-assisted Laser Desorption/Ionization Time of Flight MALDI-TOF Mass Spectrometric Analysis of Intact Proteins Larger than 100 kDa
Published on: September 9, 2013
Related Concept Videos
01:08Matrix-Assisted Laser Desorption Ionization (MALDI)
The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix material. The...
01:33Peptide Identification Using Tandem Mass Spectrometry
This technique helps gather information regarding the protein from which the peptide was obtained and to study the peptides’ amino acid sequence. Identifying peptides from a complex mixture is an important component of the growing field of...