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Updated: Jul 12, 2026

Retinal Pathophysiological Evaluation in a Rat Model
Published on: May 6, 2022
Pattern ERG, pattern VEP, and GCL thickness in diabetic patients with no diabetic retinopathy
1Eye and Ear Hospital, Naccache, Lebanon; Holy Spirit University, Jounieh, Lebanon.
Purpose:
The main objective of this study was to compare the retinal ganglion cell (RGC) function of diabetic patients without diabetic retinopathy with the RGC function of a control group, using functional tests and anatomical assessments.
Methods:
A cross-sectional prospective pilot study was conducted on two groups. We compared the results of functional tests (Pattern ERG and Pattern VEP - PERG and PVEP) and anatomical tests (macular and RNFL OCT) in a diabetic group without diabetic retinopathy to a control group. The χ2 test was used to study qualitative data, and the t test was used for quantitative data. The significance threshold was a P value less than 0.05.
Results:
A total of 37 eyes were included in the study. None of the demographic variables showed any significant association or effect on any of the two groups. GCL thickness was significantly reduced in the diabetic group in the superior, inferior, and nasal outer circles, with a P value <0.001. The amplitude of the P100 wave was significantly reduced in the diabetic group, with a P value<0.05 for the pattern sizes of 60' and 30', and the diabetic group had a longer latency for the 15' VEPs. All of the components of the PERG responses were significantly altered in the diabetic group, with a P value<0.05.
Conclusion:
Our study indicates that combining different tests may be used as an early means of detection of compromised retinal neuron function in diabetic eyes during the course of early diabetic retinopathy.
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