Closed-loop photoacoustic photothermal treatment method and system based on real-time Kalman filter temperature...

Real-time measurement and control of the temperature and thermal damage of the therapeutic target is critical to the safety and effectiveness of photothermal therapy (PTT). However, due to the lack of effective non-contact temperature control technology, it is very difficult to accurately measure and control the temperature of the target area, which may cause damage to the healthy tissues around the target area. In this paper, to ensure the effectiveness of photothermal therapy while minimizing damage to normal tissues, we propose a closed-loop photoacoustic photothermal therapy method and system based on real-time Kalman filter temperature estimation model. A prediction and observation model for the target temperature field has been established, achieving non-invasive real-time temperature measurement. At the same time, combined with the closed-loop fuzzy PID temperature regulation algorithm, we can also adjust the drive power of therapeutic laser in real time, and finally achieve the real-time control of the target temperature. After experimental validation, the system proposed in this paper achieves the temperature control accuracy of 0.47 °C and 0.76 °C on the phantoms and ex vivo, respectively. In addition, the comparison with the results of the simulated PTT experiment without the temperature observation model further verifies the advantages of this method in dynamic and static control performance. In general, this method has the potential to be used as an auxiliary means in PTT to further improve the dynamic characteristics and precision of therapy.