Neem gum and its derivatives as potential polymeric scaffold for diverse applications: a review

Naturally occurring polymers, particularly polysaccharides, are gaining significant attention for their eco-friendly, non-toxic nature and abundant availability. Neem Gum (NEG), a natural exudate from the neem tree (Azadirachta indica), is secreted as a defense mechanism to protect against microbial invasion and physical damage. Unlike common polysaccharides, NEG exhibits a distinct composition rich in bioactive constituents, including heteropolysaccharides and secondary metabolites, contributing to its diverse functional and therapeutic potential. These unique characteristics make NEG a promising biopolymer for applications in pharmaceuticals, food, cosmetics, and environmental industries, where it serves as a binding, emulsifying, gelling, and stabilizing agent. Recent advancements have focused on developing NEG composites and derivatives with enhanced properties and broader applications. Structural modifications like grafting and carboxymethylation have improved its utility in drug delivery, wound healing, and biodegradable materials. Modified NEG derivatives exhibit superior antimicrobial, anti-inflammatory, and antioxidant effects, expanding their biomedical potential in tissue engineering and controlled drug release. NEG-based hydrogels and films show promise in eco-friendly packaging and self-healing biomaterials. This review compiles NEG's diverse applications, highlighting its role in sustainable technologies and emerging fields like self-healing materials and smart polymers. It addresses challenges in scaling production, regulatory compliance, and technical constraints.