Related Experiment Video
Updated: Jul 19, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Transient monoclonal gammopathy: a single-center study.
1Servicio de Análisis Clínicos, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
Transient monoclonal gammopathies, a temporary paraprotein, are often linked to infections or autoimmune conditions. Identifying these transient cases can prevent unnecessary medical investigations for patients.
Area of Science:
- Clinical Medicine
- Hematology
- Immunology
Background:
- Monoclonal gammopathies of uncertain significance (MGUS) can be transient, presenting as a temporary serum paraprotein.
- Transient monoclonal gammopathies are characterized by the appearance and subsequent disappearance of a paraprotein.
Purpose of the Study:
- To investigate transient monoclonal gammopathies within a specific health area.
- To describe the characteristics and associated pathologies of transient monoclonal gammopathies.
Main Methods:
- Retrospective review of serum protein electrophoresis (SPEP) patterns over a 6-month period (January-June 2024).
- Analysis included patients from primary and secondary care in the Santiago de Compostela and Barbanza Sanitary Area.
- Selected patients had no hematologic pathology and a history of both monoclonal and non-monoclonal SPEP results.
Main Results:
- Eighty cases of transient monoclonal gammopathy were identified.
- The majority (85%) showed a monoclonal pattern, while 15% exhibited an oligoclonal pattern.
- Associated conditions included infectious processes (43.7%), autoimmune diseases (25%), and transplant recipients (15%).
Conclusions:
- Transient paraproteinemia should be considered by clinicians.
- Recognizing transient monoclonal gammopathy can help avoid unnecessary investigations and invasive procedures.
- This distinction is crucial when differentiating from persistent monoclonal gammopathy or suspected malignancy.
More Related Videos
05:32Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
Published on: January 7, 2019
06:08Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model
Published on: February 10, 2023
Related Concept Videos
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Gastritis II: Pathophysiology
Peptic Ulcer Disease I: Introduction
Peptic Ulcer Disease II: Pathophysiology