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Updated: Jun 12, 2025

Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
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α-Synuclein interacts directly with AP2 and regulates its binding to synaptic membranes

Karina J Vargas1, Jaqulin N Wallace2, Ian Mooney3

  • 1Cell Biology Department, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; The Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, Massachusetts, USA.

The Journal of Biological Chemistry
|April 11, 2025
PubMed
Summary

Alpha-synuclein stabilizes the clathrin adaptor protein-2 (AP2) on synaptic membranes, a key step for clathrin-mediated synaptic vesicle endocytosis. This interaction is crucial for regulating endocytosis in neurodegenerative diseases.

Keywords:
AP2endocytosissynapsesynaptic vesicle recyclingα-synuclein

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