Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 14, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.2K

Right Atrial Appendage for Aortic Valve Reconstruction.

Paighton C Miller1, Jacob R Miller2, Chelsea T Mannie2

  • 1Department of Surgery, Washington University in St. Louis School of Medicine, St Louis, Missouri.

The Annals of Thoracic Surgery
|April 11, 2025
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary: Bring back the shunt? Staged repair of pulmonary atresia with ventricular septal defect with systemic-to-pulmonary artery shunt.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.

Immunity·2026
Same author

AxioParse: streamlining Axiom Microbiome assay data processing and dataset generation.

BioTechniques·2026
Same author

OmniCellTOSG: The First Cell Text-Omic Signaling Graphs Dataset for Graph Language Foundation Modeling.

Research square·2026
Same author

Viral Co-infection in COVID-19: Prevalence and Clinical Associations of Human Pegivirus.

medRxiv : the preprint server for health sciences·2026
Same author

Hybrid vs. Norwood: An Analysis of the NPC-QIC Database to Determine Optimal Approach for High-Risk Single Ventricle Patients.

Pediatric cardiology·2026

Live atrial appendage tissue shows promise for reconstructing aortic valves in pediatric patients with congenital heart defects. This novel approach offers a potential new option for aortic valve interventions, with early results indicating feasibility and good short-term outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Biomaterials in Medicine

Background:

  • Congenital aortic valve disease, frequently bicuspid, presents challenges due to limitations of current repair tissues.
  • Existing techniques like valve replacement or pericardium use are suboptimal, lacking ideal tissue properties.
  • Prior success with right atrial appendage (RAA) tissue for pulmonary valve reconstruction informed this study.

Purpose of the Study:

  • To evaluate the preliminary results of using live RAA tissue for aortic valve reconstruction.
  • To assess the feasibility and early outcomes of this novel technique in pediatric patients.

Main Methods:

  • Six pediatric patients with unicuspid or bicuspid aortic valves and significant insufficiency underwent RAA tissue reconstruction.

More Related Videos

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.3K
Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

35.0K

Related Experiment Videos

Last Updated: May 14, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.2K
The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

83.3K
Implantation of the Syncardia Total Artificial Heart
16:11

Implantation of the Syncardia Total Artificial Heart

Published on: July 18, 2014

35.0K
  • RAA tissue was primarily used to replace the deficient right coronary leaflet.
  • External annuloplasty was performed for annular stabilization, with echocardiography used for evaluation.

    • Main Results:

    • The reconstructive procedure was successfully performed in all six patients (ages 7-18).
    • All patients were extubated in the OR with an uncomplicated hospital stay (4-8 days).
    • Follow-up (5-34 months) showed trivial to mild central aortic insufficiency in five patients and mild to moderate basal insufficiency in one.

    Conclusions:

    • Live atrial tissue demonstrates functional capacity in the aortic position.
    • This technique presents a potential new option for aortic valve interventions in select pediatric cases.
    • Long-term efficacy and durability of RAA tissue for aortic valve repair require further investigation.