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Updated: May 14, 2025

Using Nanoplasmon-Enhanced Scattering and Low-Magnification Microscope Imaging to Quantify Tumor-Derived Exosomes
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Impaired Cellular Cholesterol Homeostasis Decreases Tumor-Derived Exosome Load And Modulates Malignant Transformation

Syed Sultan Beevi1, Aishwarya Sudam Bhale2, Vinod Kumar Verma3

  • 1Cancer Biology Division, KIMS Foundation and Research Center, Krishna Institute of Medical Sciences (KIMS) Hospitals, Secunderabad, Telangana, India. drsyedsultan.b@kfrc.co.in.

Cell Biochemistry and Biophysics
|April 11, 2025
PubMed
Summary

Cholesterol accumulation in cancer cells reduces tumor-derived exosome release, hindering their ability to promote malignant transformation and metastasis. This suggests targeting cholesterol homeostasis is a promising strategy against cancer progression.

Keywords:
Cryo-SEMEMT processFilipin stainingFoci formationNano-tracking analysisScratch assay

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