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SIM2, associated with clinicopathologic features, promotes the malignant biological behaviors of endometrial carcinoma cells

  • 0Reproductive Medicine Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital) Tongji Medical College Huazhong University of Science and Technology Reproductive Medicine Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.
Bmc Cancer +

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April 11, 2025

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April 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies SIM bHLH transcription factor 2 (SIM2) as a key regulator in endometrial carcinoma (EC). High SIM2 expression indicates poor prognosis and drives EC progression, suggesting SIM2 as a potential therapeutic target.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Endometrial carcinoma (EC) is a significant threat to women's health.
  • Identifying prognostic biomarkers and therapeutic targets is crucial for improving EC patient survival.

Purpose Of The Study

  • To identify key regulators in EC progression.
  • To investigate the biological functions of SIM bHLH transcription factor 2 (SIM2) in EC.

Main Methods

  • Utilized TCGA and GEO databases for gene expression and clinical data.
  • Applied WGCNA, LASSO regression, and Cox regression for gene screening and prognostic model construction.
  • Validated SIM2's function through in vitro (cell lines) and in vivo (metastasis models) experiments.

Main Results

  • Identified 13 prognostic genes, including SIM2, and developed a predictive risk model for EC outcomes.
  • SIM2 was significantly overexpressed in EC tissues, correlating with poor prognosis.
  • SIM2 knockdown inhibited EC cell viability, induced cell cycle arrest, promoted apoptosis, and suppressed metastasis in vivo.

Conclusions

  • SIM2 acts as a prognostic biomarker and potential therapeutic target for EC.
  • SIM2 positively modulates malignant phenotypes of EC cells, impacting diagnosis and prognosis.

Keywords:

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