Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Amygdala in Memory

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

Post-traumatic Stress Disorder

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...

Coping Strategies: Emotion Focused

Coping Strategies: Emotion Focused

Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder.

Frontiers in psychiatry·2026

Same author

Efficacy, effectiveness and safety of medical cannabis in PTSD: a scoping review.

Journal of cannabis research·2026

Same author

Case Report: Prism for PTSD in severe traumatic brain injury with psychiatric comorbidities: two cases.

Frontiers in psychiatry·2026

Same author

Responsible artificial intelligence integration framework for psychiatric guidelines.

The international journal of neuropsychopharmacology·2026

Same author

Beyond access to equity: The contribution of predisposing, enabling, and need factors to psychiatric rehabilitation service utilization.

The American journal of orthopsychiatry·2026

Same author

Western Models of PTSD Rehabilitation Among Military Veterans: A Narrative Comparative Review and Policy Implications for Israel.

Healthcare (Basel, Switzerland)·2026

Search research articles

Related Experiment Video

Updated: May 14, 2025

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Amygdala EFP Neurofeedback Effects on PTSD Symptom Clusters and Emotional Regulation Processes.

Nadav Goldental¹, Raz Gross², Daniela Amital³

¹Division of Psychiatry, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.

Journal of Clinical Medicine

|April 12, 2025

Summary

Amygdala-derived-EEG-fMRI-Pattern neurofeedback (Amyg-EFP-NF) effectively reduces post-traumatic stress disorder (PTSD) symptoms across all clusters. Emotion regulation may be a key mechanism driving sustained symptom improvement after treatment.

Keywords:

EFP-neurofeedback amygdala downregulation emotion regulation self-neuromodulation

More Related Videos

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

Related Experiment Videos

Last Updated: May 14, 2025

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Brain Imaging Investigation of the Neural Correlates of Emotion Regulation

Published on: August 26, 2011

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Real-time fMRI Biofeedback Targeting the Orbitofrontal Cortex for Contamination Anxiety

Published on: January 20, 2012

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

Area of Science:

Neuroscience
Psychiatry
Clinical Psychology

Background:

Post-traumatic stress disorder (PTSD) presents with diverse symptom clusters.
Amygdala-derived-EEG-fMRI-Pattern neurofeedback (Amyg-EFP-NF) targets amygdala activity regulation in PTSD.
Differential treatment responses across PTSD symptom clusters necessitate targeted interventions.

Purpose of the Study:

To evaluate the efficacy of Amyg-EFP-NF across PTSD symptom clusters.
To assess the impact of Amyg-EFP-NF on emotion regulation processes.
To investigate the relationship between emotion regulation and symptom improvement post-treatment.

Main Methods:

Combined analysis of 128 PTSD patients from three Amyg-EFP-NF clinical trials.
Assessment of PTSD symptom clusters using CAPS-5 subscales.
Evaluation of emotion regulation using the Emotion Regulation Questionnaire (ERQ).

Main Results:

Amyg-EFP-NF significantly reduced all PTSD symptom clusters immediately post-treatment.
Symptom improvements were maintained at three-month follow-up, with arousal/reactivity showing continued gains.
Large effect sizes (η²p = 0.23–0.35) were observed across symptom clusters.
Emotion regulation processes explained 17% of the variance in follow-up symptom improvement.

Conclusions:

Amyg-EFP-NF demonstrates broad efficacy in reducing PTSD symptoms across all clusters.
Emotion regulation processes may act as a significant mechanism underlying sustained treatment benefits.
Amyg-EFP-NF is a promising, comprehensive treatment for PTSD with lasting effects.