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The Current Landscape of Clinical Trials
Geeta Joshi1, Tara K Bhandari2, Pushkar Joshi3
1Department of Medical Education, UTHealth San Antonio, San Antonio, TX 78229, USA.
Journal of Clinical Medicine
|April 12, 2025
Summary
Clinical trial research is increasing, with cancer trials being most common. However, underrepresentation of diverse populations and limited global reach hinder equitable health outcomes.
Area of Science:
- Medical research
- Clinical trial methodology
- Public health
Background:
- Clinical trials are vital for evaluating new medical treatments' safety and efficacy.
- Understanding the historical trends and current state of clinical trials is crucial.
Purpose of the Study:
- To analyze the landscape, challenges, and innovations in clinical trials over the past century.
- To identify patterns in trial design, sponsorship, demographics, and geographical distribution.
Main Methods:
- Comprehensive analysis of clinical trials registered on ClinicalTrials.gov.
- Data extraction and analysis of patterns in trial design, sponsorship, participant demographics, and geographical distribution.
Main Results:
- Clinical trial registrations show a continuous increase, peaking in 2021 due to the COVID-19 pandemic.
- Cancer trials dominate, with randomized controlled trials (RCTs) as the prevalent design.
- Challenges include demographic underrepresentation (pediatric, elderly, minority), limited global distribution, and insufficient results reporting.
Conclusions:
- The study highlights persistent challenges in clinical trial inclusivity and global reach.
- Addressing disparities in health outcomes requires more equitable and globally distributed research.
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