AI-Driven Data Analysis for Asthma Risk Prediction

Background: Asthma is a well-known otolaryngological and immunological disorder that affects patients worldwide. Currently, the primary diagnosis relies on a combination of clinical history, physical examination findings consistent with asthma, and objective evidence of reversible airflow obstruction. However, the diagnostic process can be invasive and time-consuming, which limits clinical efficiency and accessibility. Objectives: In this study, an AI-based prediction system was developed, leveraging voice changes caused by respiratory contraction due to asthma to create a machine learning (ML)-based clinical decision support system. Methods: A total of 1500 speech samples-comprising high-pitch, normal-pitch, and low-pitch recitations of the phonemes [i, a, u]-were used. Long-Term Average Spectrum (LTAS) and Single-Frequency Filtering Cepstral Coefficients (SFCCs) were extracted as features for classification. Seven machine learning algorithms were employed to assess the feasibility of asthma prediction. Results: The Decision Tree, CNN, and LSTM models achieved average accuracies above 0.8, with results of 0.88, 0.80, and 0.84, respectively. Observational results indicate that the Decision Tree model performed best for high-pitch phonemes, whereas the LSTM model outperformed others in normal-pitch and low-pitch phonemes. Additionally, to validate model efficiency and enhance interpretability, feature importance analysis and overall average spectral analysis were applied. Conclusions: This study aims to provide medical clinicians with accurate and reliable decision-making support, improving the efficiency of asthma diagnosis through AI-driven acoustic analysis.