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Updated: May 14, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Biosynthesis and Its Regulatory Mechanisms of 2-(2-Phenylethyl)chromones in Agarwood
Wenli Wu1, Xiaoyang Jiang1, Luyuan Jiang1
1State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Tree Breeding and Cultivation of National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China.
Abstract:
Agarwood, a highly prized traditional medicinal material and natural spice, holds significant economic and medicinal value. Widely utilized as a fragrant agent, it is also employed in the treatment of diverse ailments, including rheumatism, fever, asthma, bronchitis, cancer, and gastrointestinal or reproductive disorders. These functions are primarily attributed to the accumulation of 2-(2-phenylethyl)chromones (PECs), a class of bioactive compounds. In recent years, PECs have emerged as critical components in the development of agarwood-derived pharmaceuticals and commercial products, garnering substantial scientific attention. This review consolidates current advancements in the structure and function of PECs and examines and discusses the structural genes and regulatory transcription factors associated with PECs biosynthesis. By synthesizing this knowledge, this review establishes a foundation for elucidating the complete biosynthetic pathways and regulatory mechanisms governing PECs production, thereby facilitating future research and applications.
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