Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modified individualized titanium mesh in orbital floor reconstruction for preventing exposure.

Laryngoscope investigative otolaryngology·2023
Same author

Mixed Reality Combined with Surgical Navigation in Resection of Micro- and Mini-Tumors of the Parotid Gland: A Pilot Study.

The Laryngoscope·2023
Same author

Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro.

Biomimetics (Basel, Switzerland)·2023
Same author

Development and Validation of Nomograms Predicting the 5- and 8-Year Overall and Cancer-Specific Survival of Bladder Cancer Patients Based on SEER Program.

Journal of clinical medicine·2023
Same author

[Association between genetic polymorphism of tumor necrosis factor and chronic severe hepatitis B in patients].

Zhonghua yi xue za zhi·2007
Same author

In vivo translational inaccuracy in Escherichia coli: missense reporting using extremely low activity mutants of Vibrio harveyi luciferase.

Biochemistry·2007

Related Experiment Video

Updated: Jul 17, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K

3D-Printed Polycaprolactone/Hydroxyapatite Bionic Scaffold for Bone Regeneration.

Feng-Ze Wang1, Shuo Liu1, Min Gao2

  • 1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology and National Center for Stomatology and National Clinical Research Center for Oral Diseases and National Engineering Research Center of Oral Biomaterials and Digital Medical Devices and Beijing Key Laboratory of Digital Stomatology and NHC Key Laboratory of Digital Stomatology and NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing 100081, China.

Polymers
|April 12, 2025
PubMed
Summary

Bionic bone scaffolds using 3D printing offer alternatives to traditional grafts. A 55% infill density gyroid scaffold showed optimal properties for bone defect repair.

Keywords:
bionic scaffoldbone formationgyroidhydroxyapatite (HA)polycaprolactone (PCL)three-dimensional printing

More Related Videos

Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.0K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K

Related Experiment Videos

Last Updated: Jul 17, 2026

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

9.7K
Novel Process for 3D Printing Decellularized Matrices
08:14

Novel Process for 3D Printing Decellularized Matrices

Published on: January 7, 2019

7.0K
Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs
10:19

Ceramic Omnidirectional Bioprinting in Cell-Laden Suspensions for the Generation of Bone Analogs

Published on: August 8, 2022

1.8K

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Additive Manufacturing

Background:

  • Autologous bone grafts have limitations including donor site morbidity and material scarcity.
  • Three-dimensional (3D) printing, specifically fused deposition modeling (FDM), offers a promising approach for fabricating bionic bone scaffolds.
  • Gyroid-structured scaffolds are of interest for mimicking cancellous bone architecture, but their FDM fabrication and optimal design parameters require further investigation.

Purpose of the Study:

  • To investigate the fabrication and properties of polycaprolactone/hydroxyapatite (PCL/HA) gyroid scaffolds using FDM.
  • To determine the influence of infill density on the pore size, hydrophilicity, mechanical properties, and in vitro biological performance of these scaffolds.
  • To identify an optimal gyroid scaffold design for bone defect repair.

Main Methods:

  • Polycaprolactone/hydroxyapatite (PCL/HA) scaffolds were fabricated using FDM with varying infill densities (40-60%).
  • A solvent-free filament preparation method was employed.
  • Scaffolds were characterized using scanning electron microscopy (SEM), and their hydrophilicity, mechanical properties, and in vitro cellular responses (alkaline phosphatase activity, calcium deposition) were evaluated.

Main Results:

  • All fabricated scaffolds exhibited interconnected porous structures.
  • The scaffold with 55% infill density presented an optimal pore size of 465 ± 63 μm.
  • This 55% infill density scaffold demonstrated superior hydrophilicity, mechanical properties comparable to natural cancellous bone, and enhanced cellular activity, including bridging, alkaline phosphatase (ALP) activity, and calcium salt deposition.

Conclusions:

  • The infill density significantly impacts the properties of FDM-fabricated gyroid scaffolds.
  • A 55% infill density results in optimal pore size, mechanical strength, and biological performance for PCL/HA gyroid scaffolds.
  • These findings provide valuable insights for designing advanced gyroid scaffolds for bone regeneration applications via FDM.