Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

3.3K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.3K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

3.6K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.6K
Bone Remodeling01:40

Bone Remodeling

38.0K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.0K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.3K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anatomical variations of hepatic and pancreatic vascularization: A comprehensive review.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026
Same author

Biomaterials in cartilage damage.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026
Same author

Collagen supplementation and bone health - a narrative review.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026
Same author

Role of stem cells in articular cartilage repair - a narrative review.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026
Same author

Body mass index as a determinant of surgical outcomes in total hip arthroplasty.

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026
Same author

Urinary tract infections in patients undergoing orthopaedic procedures: A contemporary review (2021-2026).

Wiadomosci lekarskie (Warsaw, Poland : 1960)·2026

Related Experiment Video

Updated: May 14, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.4K

Bone mineral density and pandemic.

Paweł I Kamińsk1, Firoz Rizvi2, Mateusz Trubalski1

  • 1STUDENT SCIENTIFIC ASSOCIATION AT THE DEPARTMENT OF REHABILITATION AND ORTHOPEDICS, MEDICAL UNIVERSITY OF LUBLIN, LUBLIN, POLAND.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|April 12, 2025
PubMed
Summary

The COVID-19 pandemic negatively impacted bone mineral density (BMD) through reduced activity, stress, and infection. Preventive strategies are crucial to mitigate long-term bone health risks.

Keywords:
bone minerał densitypandemicsCOVID-19bone diseasesosteoporosis

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.1K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

83.0K

Related Experiment Videos

Last Updated: May 14, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.4K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

2.1K
Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

83.0K

Area of Science:

  • Orthopedics
  • Public Health
  • Endocrinology

Background:

  • The COVID-19 pandemic presented unprecedented challenges to global physical and mental well-being.
  • Significant lifestyle alterations, including reduced physical activity and altered dietary habits, became widespread.
  • The direct and indirect effects of SARS-CoV-2 infection on various physiological systems, including skeletal health, warrant thorough investigation.

Purpose of the Study:

  • To systematically review and synthesize the evidence on how pandemic-related factors influence bone mineral density (BMD).
  • To identify specific lifestyle changes, psychological stressors, and viral impacts affecting bone health.
  • To highlight potential long-term skeletal consequences and the need for targeted interventions.

Main Methods:

  • Comprehensive literature search across multiple databases for relevant studies.
  • Inclusion of observational studies, systematic reviews, and meta-analyses examining pandemic effects on BMD.
  • Analysis of factors including physical activity, stress, depression, diet, SARS-CoV-2 infection, and corticosteroid use.

Main Results:

  • Decreased physical activity, depression, and dietary changes were associated with reduced BMD, particularly in the lumbar spine and femoral neck.
  • SARS-CoV-2 infection and corticosteroid therapy increased osteoporosis risk, with cytokine storms exacerbating bone resorption.
  • Complex interactions between obesity, sedentary behavior, and BMD were observed, influencing fracture risk.

Conclusions:

  • The COVID-19 pandemic poses significant risks to bone health, potentially leading to long-term adverse skeletal effects.
  • Preventive measures focusing on physical activity, stress management, and judicious medication use are essential.
  • Further research is imperative to elucidate long-term consequences and develop effective therapeutic strategies against COVID-19-related bone loss.