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A Quick Phenotypic Neurological Scoring System for Evaluating Disease Progression in the SOD1-G93A Mouse Model of ALS
Published on: October 6, 2015
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SOD1-ALS mimicking an inflammatory neuropathy: a case report
Hanna Sophie Lapp1, René Günther1,2
1Department of Neurology, Technische Universität Dresden, Dresden, Germany and.
Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|April 12, 2025
Summary
A patient with rapidly progressing SOD1-Amyotrophic Lateral Sclerosis (ALS) showed significant improvement after starting tofersen treatment. This intervention notably slowed disease progression and reduced neurofilament levels.
Area of Science:
- Neuroscience
- Neurology
- Genetics
Background:
- Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease.
- Mutations in the Superoxide Dismutase 1 (SOD1) gene are a known cause of familial ALS.
- Accurate diagnosis can be challenging due to overlapping symptoms with other neuropathies.
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