Evaluation of digit ratio (2D:4D) and its relationship with skin sebum level in patients with basal cell carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.This study found no link between the 2D:4D ratio and basal cell carcinoma (BCC). However, male BCC patients showed higher skin sebum levels, suggesting a potential role in disease evaluation.
Area Of Science
- Dermatology
- Oncology
- Endocrinology
Background
- Basal cell carcinoma (BCC) development is primarily linked to UV exposure.
- The Sonic Hedgehog (SHH) pathway is often upregulated in BCC, potentially increasing sebocyte numbers.
- Sex hormones may influence skin cancer development, indicated by sex differences in tumor formation.
Purpose Of The Study
- To investigate the relationship between the 2D:4D ratio and skin sebum levels in patients with basal cell carcinoma (BCC).
Main Methods
- Finger length measurements were obtained using digital calipers to determine the 2D:4D ratio.
- Skin sebum levels were quantified using a sebumeter on facial areas.
Main Results
- No significant correlation was found between the 2D:4D ratio and BCC in either patients or controls.
- Patients with BCC exhibited higher T scores and total sebum scores (TSS) compared to controls.
- Male BCC patients demonstrated significantly higher T scores, U scores, and TSS than male controls; this difference was not observed in female patients.
Conclusions
- The 2D:4D ratio is not correlated with basal cell carcinoma.
- Elevated skin sebum levels, particularly in males, may be associated with BCC.
- Further research into the BCC-sebum level relationship could aid in disease occurrence and prognosis assessment.
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