Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testes: Histology01:27

Testes: Histology

519
A tough, fibrous membrane, the tunica albuginea, covers the testes, extending inward to form fibrous partitions or septa, dividing them into internal compartments called lobules. Each lobule has 1 to 3 tightly coiled seminiferous tubules where sperm production occurs. These tubules merge into a tubular network at the back of the testis, known as the rete testis. It connects to 15 to 20 efferent ductules, leading to the epididymis.
The spermatogenic cells, responsible for producing sperm, are...
519
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

238
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
238
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

123
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
123
Testes: Gross Anatomy01:19

Testes: Gross Anatomy

1.4K
The testes, also known as testicles, are the male gonads. They are housed within the scrotum, a sac-like structure located beneath the penis. The scrotum's primary role is to regulate the temperature of the testes, which is crucial for sperm production.
Each testis is surrounded by the tunica albuginea, a dense connective tissue layer that provides structural support and protection. This layer is covered by an outer serous membrane called the tunica vaginalis, which helps reduce friction...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Persistent Pyelonephritis and Renal Abscess due to <i>Mycoplasma hominis</i> in an Immunocompromised Patient: A Case Report.

Case reports in infectious diseases·2026
Same author

High-Dose Methotrexate as CNS Prophylaxis in Ultra High-Risk Large B-Cell Lymphoma: An International Multicenter Analysis.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Glofitamab plus gemcitabine and oxaliplatin for relapsed/refractory DLBCL: 3-year follow-up of STARGLO.

Blood advances·2026
Same author

Obinutuzumab, lenalidomide, and venetoclax for the initial treatment of patients with advanced-stage follicular lymphoma: Results of the Phase Ib/II LEVERAGE study.

HemaSphere·2026
Same author

Tafasitamab plus lenalidomide and R-CHOP versus R-CHOP for first-line treatment of patients with high-risk diffuse large B-cell lymphoma (frontMIND): a global, phase 3, randomised, double-blind, placebo-controlled trial.

Lancet (London, England)·2026
Same author

Safety and efficacy of allogeneic CD19-directed CAR-T therapy CTX110 in relapsed/refractory B-cell non-Hodgkin lymphoma.

Blood advances·2026
Same journal

Neoadjuvant and adjuvant therapy in uveal melanoma: toward systemic control of a systemic disease.

Cancer treatment reviews·2026
Same journal

Antiangiogenic therapies in gastric cancer: future directions for 2026 and beyond: an UNICANCER gastrointestinal group (UCGI) perspective.

Cancer treatment reviews·2026
Same journal

Treatment of breast cancer brain metastases in the era of novel drugs.

Cancer treatment reviews·2026
Same journal

Standardization of objectives and response criteria for neoadjuvant immunotherapy in resectable squamous cell carcinoma of the head and neck.

Cancer treatment reviews·2026
Same journal

Precision targeting of CLDN18.2: A new therapeutic paradigm for gastric cancer.

Cancer treatment reviews·2026
Same journal

Beyond body surface area: CT-derived body composition as a predictor of chemotherapy toxicity and survival in pancreatic ductal adenocarcinoma: a systematic review.

Cancer treatment reviews·2026
See all related articles

Related Experiment Video

Updated: May 14, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

942

Primary testicular lymphoma.

Brian T Grainger1, Chan Y Cheah2

  • 1Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Cancer Treatment Reviews
|April 12, 2025
PubMed
Summary
This summary is machine-generated.

Primary testicular lymphoma (PTL), mostly diffuse large B cell lymphoma (DLBCL), has a high risk of relapse. Understanding molecular subtypes and treatment advances is crucial for improving patient outcomes and preventing central nervous system (CNS) spread.

Keywords:
LymphomaManagementPathology

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K
Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
07:39

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

12.1K

Related Experiment Videos

Last Updated: May 14, 2025

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues
07:17

Author Spotlight: Advancing the Detection of Low-Frequency Mutations in Cancer Tissues

Published on: August 23, 2024

942
Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.1K
Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
07:39

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

12.1K

Area of Science:

  • Oncology
  • Hematology
  • Immunology

Background:

  • Primary testicular lymphoma (PTL) is a rare extranodal lymphoma, predominantly diffuse large B cell lymphoma (DLBCL) with an activated B-cell-like (ABC) profile.
  • PT-DLBCL presents a high risk for contralateral testis and central nervous system (CNS) relapse, indicating an unmet clinical need.

Purpose of the Study:

  • To review the epidemiology, clinical presentation, and diagnostic evaluation of PT-DLBCL.
  • To discuss recent advances in molecular biology, including DLBCL subtypes, immune escape, and sustained signaling in disease pathophysiology.
  • To appraise clinical trials and modern treatment recommendations, focusing on radiotherapy and CNS relapse prevention.

Main Methods:

  • Literature review of epidemiological data.
  • Analysis of clinical presentation and diagnostic approaches.
  • Review of molecular biology findings and clinical trial data.

Main Results:

  • The majority of PT-DLBCL cases exhibit an ABC gene expression profile.
  • High risk of contralateral testis and CNS relapse is a significant clinical challenge.
  • Advances in understanding molecular subtypes and immune escape mechanisms are emerging.

Conclusions:

  • Modern treatment strategies incorporate updated guidance on radiotherapy.
  • Evidence-based approaches for preventing CNS relapse are being refined.
  • Continued research into molecular subtypes and targeted therapies is essential for improving PT-DLBCL management.