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Drug Regulation

Drug Regulation

Drug regulation encompasses the management of drug usage by evaluating its safety and efficacy through assessments conducted by regulatory authorities. Regrettably, the history of drug regulation is marred by several catastrophic events. One such incident is the Elixir Sulfanilamide tragedy, in which the toxic compound diethyl glycol was included in a sweet-tasting medication, leading to numerous fatalities. This event prompted the enactment of the Food, Drug, and Cosmetic Act in 1938. Under...

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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

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Effectiveness of School Fluoride Delivery Programs: A Community Guide Systematic Review.

Susan O Griffin¹, Mei Lin¹, Christina R Scherrer²

¹Division of Oral Health, Centers for Disease Control and Prevention, Atlanta, Georgia.

American Journal of Preventive Medicine

|April 12, 2025

Summary

This summary is machine-generated.

School-based fluoride varnish programs significantly reduce dental caries in children. These programs are effective in both permanent and primary teeth, offering a vital preventive dental service.

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Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Area of Science:

Public Health
Pediatric Dentistry
Preventive Medicine

Background:

Dental caries remains a prevalent, yet preventable, childhood disease.
Many children lack routine access to preventive dental services in clinical settings.
School-based fluoride varnish programs offer a strategy to increase service delivery.

Purpose of the Study:

To systematically review the effectiveness of school-based fluoride varnish programs in preventing dental caries.
To assess the impact of these programs on fluoride varnish receipt and caries incidence.

Main Methods:

Systematic review following Community Guide methods.
Searched databases for studies published through December 2023.
Included English-language, peer-reviewed studies from upper-middle- or high-income countries; data synthesized using median RR and IQI.

Main Results:

31 studies involving 60,780 students were included; 25 were randomized controlled trials.
School fluoride varnish programs reduced caries initiation by 32% in permanent teeth and 25% in primary teeth.
Effectiveness was largely consistent across settings, though inversely related to socioeconomic status in some cases.

Conclusions:

Approximately 30% of states lack school fluoride varnish programs.
Barriers include Medicaid reimbursement limitations for non-dental providers for children over age 6.
School-based programs are a proven method for caries prevention, but implementation challenges persist.