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New anti-neuroinflammatory triterpenoid saponins from the leaves of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim
MingYuan Guo1, Juan Pan1, MengMeng Li1
1"Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education", Traditional Chinese Medicine (TCM) Biological Genetics (Heilongjiang Province Double First-class Construction Interdiscipline), Harbin 150030, China.
Abstract:
Five unknown natural triterpenoid saponins (1-5) and fifteen known triterpenoid saponins (6-20) were isolated from the leaves of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. The structures of the new compounds were elucidated by a combination of chemical methods and spectroscopic analyses. Biological studies showed that compounds 1-6, 11-15, 19, and 20 demonstrated significant effects that inhibit NO production in BV2 cells induced by LPS.

