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Updated: May 13, 2025

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
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Resetting the aging clock through epigenetic reprogramming: Insights from natural products

Xin Liu1, Jing Feng1, Madi Guo1

  • 1State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Department of Pharmacology, College of Pharmacy, and Department of Cardiology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China; State Key Laboratory -Province Key Laboratories of Biomedicine-Pharmaceutics of China, and Key Laboratory of Cardiovascular Research, Ministry of Education, College of Pharmacy, Harbin 150081, China; Research Unit of Noninfectious Chronic Diseases in Frigid Zone (2019RU070), Chinese Academy of Medical Sciences, Harbin 150081, China.

Pharmacology & Therapeutics
|April 12, 2025
PubMed
Summary

Epigenetic reprogramming is a hallmark of aging. Natural products show potential in correcting these changes for anti-aging therapies and improving healthspan.

Keywords:
AgingAging clockEpigenetic modificationsLongevityNatural products

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