Related Experiment Video
Updated: May 13, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
407
Spatial Metabolomics in Acute Kidney Injury
Guanshi Zhang1, W Brian Reeves2
1Division of Nephrology, Department of Medicine, University of Texas Health San Antonio, San Antonio, TX; Audie L. Murphy Memorial VA Hospital, South Texas Veterans Health Care System, San Antonio, TX.
Seminars in Nephrology
|April 12, 2025
Summary
Spatial metabolomics aids in understanding acute kidney injury (AKI) by revealing metabolic shifts like altered lipid metabolism and energy production pathways. This approach enhances diagnosis and therapeutic strategies for kidney disease.
Area of Science:
- Nephrology
- Biochemistry
- Medical Imaging
Background:
- Acute kidney injury (AKI) is a prevalent condition with significant morbidity, mortality, and healthcare costs.
- Effective diagnosis and management of AKI are crucial for improving patient outcomes.
- Advancements in renal imaging and omics offer new insights but pose challenges for comprehensive atlasing.
Purpose of the Study:
- To review the application of mass spectrometry imaging-based spatial metabolomics in studying AKI.
- To explore the pathophysiological connections in AKI using spatial metabolomics.
- To highlight the role of spatial metabolomics in understanding kidney injury.
Main Methods:
- Utilizing mass spectrometry imaging (MSI) for spatial metabolomics.
- Analyzing ischemia- and toxin-induced AKI in animal models and human patients.
- Integrating multimodal imaging and omics technologies.
Main Results:
- Spatial metabolomics provides deeper insights into dysregulated lipid metabolism in AKI.
- Identified a metabolic shift from the tricarboxylic acid cycle to glycolytic flux in AKI.
- Demonstrated the link between metabolic changes and functional/structural kidney damage.
Conclusions:
- Spatial metabolomics is a powerful tool for understanding AKI pathophysiology.
- Further research in renal multimodal imaging and omics is essential.
- This approach can advance diagnostic, mechanistic, and therapeutic perspectives in AKI.
