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Time to Injection Laryngoplasty: A Quality Improvement Analysis
Jennifer A Silver1, Carolina Peralta1, Alicia Belaiche2
1Department of Otolaryngology - Head and Neck Surgery, McGill University, Montréal, Canada.
Journal of Voice : Official Journal of the Voice Foundation
|April 12, 2025
Summary
Early vocal fold augmentation injection laryngoplasty with hyaluronic acid is effective for glottic insufficiency. Most patients receive timely treatment, especially those with aspiration or dysphagia, with antithrombotic therapy being a key delay factor.
Area of Science:
- Otolaryngology
- Speech and Hearing Science
- Medical Technology
Background:
- Vocal fold (VF) augmentation injection laryngoplasty using hyaluronic acid offers rapid, office-based treatment for glottic insufficiency.
- Early intervention (within 3 months) can prevent hospital readmissions, aspiration pneumonia, and reduce the need for permanent surgical procedures like Type 1 thyroplasty.
Purpose of the Study:
- To determine the average time to first injection laryngoplasty for glottic insufficiency.
- To characterize patient demographics undergoing VF medialization.
- To identify factors causing treatment delays.
Main Methods:
- A retrospective quality improvement assessment analyzed patients receiving initial hyaluronic acid injection for glottic insufficiency between April 2021 and March 2024.
- Data on patient demographics and reasons for delay (e.g., antithrombotic therapy, voice therapy, anxiety, infections) were extracted from clinical records.
Main Results:
- 139 patients underwent VF augmentation; 48.9% female, 51.1% male, average age 66.2 years.
- Vocal cord paralysis (71.9%) was the most common indication, followed by VF atrophy (22.3%).
- Mean time to injection was 21.7 days; patients with aspiration/dysphagia were injected within 9.8 days. Patients without delaying factors received injections within 1.44 days.
Conclusions:
- The institution achieves early injection laryngoplasty in most patients, often within two days when no delaying factors are present.
- Antithrombotic therapy was identified as the primary factor delaying treatment.
- Prompt injection is crucial for managing glottic insufficiency and associated complications.

