Management and survival trends for diffuse gliomas diagnosed at a single neurooncology center in China during 2000 to...

Currently reported survival outcomes for gliomas exhibit significant variability and controversy. In this study, we aim to provide survival data in Chinese populations by conducting a retrospective analysis of management and survival trends in a large cohort of glioma patients from a single institute in China. A total of 1206 patients with newly diagnosed gliomas treated between 2000 and 2020 were enrolled, including 537 glioblastoma (WHO grade 4), 450 astrocytomas (grade 2/3) and 219 oligodendroglial tumors (grade 2/3). The estimated overall survival at 5 years was 18.9% for glioblastoma, 58.8% for astrocytomas, and 80.7% for oligodendroglial tumors, while median survival was 17.2 months, 82.8 months, and not reached, respectively. The survival trend has increased over the past decades for all types of gliomas. Additionally, similar survival trends were observed between grade 2 and 3 IDH-mutant gliomas. Rising trends were observed in patients undergoing postsurgical radiation and chemotherapy. Multivariate analysis identified adjuvant radiochemotherapy as an independent factor for better prognosis in glioblastoma and astrocytomas. In summary, despite its retrospective nature, this cohort of glioma patients exhibits favorable survival outcomes compared to global statistics, indicating a geographical disparity in glioma prognosis. The promotion of adjuvant chemoradiotherapy contributes to improved prognosis.