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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Stereoisomerism in Trimacrocyclic Structures Fused by a Pillar[6]arene and Two [8]Cycloparaphenylenes
Hanchi Zhong1, Kai Lan1, Jiao Ming1
1College of Chemistry, Sichuan University, Chengdu 610064, China.
Abstract:
Stereoisomerism in pillararenes, particularly chiral isomerism from atropisomers, has intrigued organic chemists. Herein, we report the synthesis and characterization of a trimacrocyclic system formed by fusing two [8]cycloparaphenylenes with a pillar[6]arene. This system exhibits unique stereoisomerism, yielding a racemic mixture and a meso compound. The isomers were characterized using NMR, HRMS, and single crystal X-ray diffraction. This study offers valuable insights into constructing chiral isomers in macrocycles and enriches our understanding of stereochemistry.
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