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Updated: Jun 14, 2025

A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis
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A Gut-on-a-Chip Model to Study the Gut Microbiome-Nervous System Axis

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Gastrointestinal (GI)-lung-brain axis

Catalina Bazacliu1, Juan Carlos Roig1, Josef Neu1

  • 1University of Florida, Division of Neonatology, 1600 SW Archer Road, Gainesville, FL, 32608, USA.

Seminars in Fetal & Neonatal Medicine
|April 13, 2025
PubMed

Insights

The GI tract-lung-brain axis links gut, lung, and brain health, especially in developing preterm neonates. Microbiota critically influence this axis, impacting health and disease via neural, hormonal, and immune pathways.

Area of Science:

  • Microbiology
  • Neuroscience
  • Gastroenterology
  • Neonatology

Background:

  • The gastrointestinal (GI) tract-lung-brain axis is a complex communication network.
  • This axis involves the gut, lungs, and central nervous system.
  • It is crucial in preterm neonates due to their developing immune and nervous systems.

Purpose of the Study:

  • To introduce the GI tract-lung-brain axis.
  • To explain its interactive mechanisms.
  • To discuss perturbations affecting the system and their roles in health and disease.

Main Methods:

  • Review of existing literature on the GI tract-lung-brain axis.
  • Analysis of communication pathways (neural, hormonal, immunological).
  • Examination of the role of microbiota as key mediators.

Main Results:

  • The GI tract-lung-brain axis is a significant pathway in preterm neonates.
  • Microbiota play a key role in mediating this axis.
  • Neural, hormonal, and immunological pathways are pivotal.

Conclusions:

  • Understanding the GI tract-lung-brain axis is vital for preterm neonate health.
  • Perturbations in this axis can lead to various conditions.
  • Further research into this axis can inform disease pathogenesis and treatment.

Keywords:
GI tract-lung-brain axisHormonesImmunologyMetabolomeMicrobiomeMicrobiota

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