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Gastrointestinal (GI)-lung-brain axis.

Catalina Bazacliu1, Juan Carlos Roig1, Josef Neu1

  • 1University of Florida, Division of Neonatology, 1600 SW Archer Road, Gainesville, FL, 32608, USA.

Seminars in Fetal & Neonatal Medicine
|April 13, 2025
PubMed
Summary
This summary is machine-generated.

The GI tract-lung-brain axis links gut, lung, and brain health, especially in developing preterm neonates. Microbiota critically influence this axis, impacting health and disease via neural, hormonal, and immune pathways.

Keywords:
GI tract-lung-brain axisHormonesImmunologyMetabolomeMicrobiomeMicrobiota

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Area of Science:

  • Microbiology
  • Neuroscience
  • Gastroenterology
  • Neonatology

Background:

  • The gastrointestinal (GI) tract-lung-brain axis is a complex communication network.
  • This axis involves the gut, lungs, and central nervous system.
  • It is crucial in preterm neonates due to their developing immune and nervous systems.

Purpose of the Study:

  • To introduce the GI tract-lung-brain axis.
  • To explain its interactive mechanisms.
  • To discuss perturbations affecting the system and their roles in health and disease.

Main Methods:

  • Review of existing literature on the GI tract-lung-brain axis.
  • Analysis of communication pathways (neural, hormonal, immunological).
  • Examination of the role of microbiota as key mediators.

Main Results:

  • The GI tract-lung-brain axis is a significant pathway in preterm neonates.
  • Microbiota play a key role in mediating this axis.
  • Neural, hormonal, and immunological pathways are pivotal.

Conclusions:

  • Understanding the GI tract-lung-brain axis is vital for preterm neonate health.
  • Perturbations in this axis can lead to various conditions.
  • Further research into this axis can inform disease pathogenesis and treatment.