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Related Concept Videos

Brain Imaging01:14

Brain Imaging

195
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
195

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Related Experiment Video

Updated: May 13, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

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Global experience in brain amyloid imaging.

Luca Filippi1, Orazio Schillaci1

  • 1Department of Biomedicine and Prevention, University Tor Vergata, Rome, Italy.

Seminars in Nuclear Medicine
|April 13, 2025
PubMed
Summary
This summary is machine-generated.

Brain amyloid PET imaging is vital for Alzheimer's diagnosis. While advanced tracers improve accessibility, global use varies, highlighting the need for standardization and equitable access to this crucial diagnostic tool.

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Area of Science:

  • Neurology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Brain amyloid imaging, particularly positron emission tomography (PET), is essential for diagnosing Alzheimer's disease (AD).
  • Early tracers like [¹¹C]Pittsburgh Compound-B ([¹¹C]PiB) enabled in vivo visualization of amyloid-β (Aβ) plaques.
  • Development of ¹⁸F-labeled tracers has enhanced accessibility and imaging capabilities for amyloid deposition.

Purpose of the Study:

  • To review the current state and global disparities in amyloid PET imaging for neurodegenerative disorders.
  • To discuss the clinical utility, challenges, and future directions of amyloid PET in AD diagnosis and management.
  • To highlight the importance of integrating amyloid PET with other biomarkers and addressing access inequities.

Main Methods:

  • Review of existing literature on amyloid PET tracers and their clinical application.
  • Analysis of geographical variations in research and implementation of amyloid PET.
  • Discussion of emerging trends including AI and novel tracers.

Main Results:

  • Amyloid PET is increasingly adopted in high-income countries for dementia diagnosis and patient selection for therapies.
  • Significant global disparities exist in access to amyloid PET due to infrastructure, cost, and regulatory issues.
  • Integration with tau PET, CSF, and plasma biomarkers is being explored to enhance diagnostic accuracy.

Conclusions:

  • Amyloid PET is a sensitive and specific tool, but its clinical utility requires careful consideration, especially in asymptomatic individuals.
  • Global standardization, equitable access, and ethical considerations are crucial for optimizing amyloid PET's role.
  • Advancements in AI and new tracers promise to further refine amyloid PET's impact on Alzheimer's disease research and clinical practice.