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Outcomes of Adolescent LBCL Patients Treated With Adult Type Chemotherapy: A Single Center Experience
Riad El Fakih1, Taimoor Hussain2, Oudai Sahwan3
1King Faisal Specialist Hospital and Research Center, Riyadh, KSA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Background:
Lymphoma is the most common cancer in adolescents. Outcome disparities based on the locus of care are increasingly recognized in this age group.
Materials And Methods:
We report outcomes of LBCL patients between 14 and 21 who were treated at an adult center using adult type chemotherapy.
Results:
Sixty-four patients, median age 19 were analyzed. 82.8% were DLBCL, 17.2% were PMBCL; 21.9% stage I, 31.3% stage II, 7.8% stage III, and 39 % stage IV; 18.8% "very good", 62.5% "good" and 18.8% "poor" RIPI score. The median follow-up period was 68.8 months. The 5 years OS was 94.3%, and the 5 years EFS was 78.3%. High RIPI patients had a worse OS. High RIPI, B symptoms, ABC cell of origin and PMBCL had worse EFS.
Conclusion:
Pediatric protocol use should be restricted to patients at higher risk of events rather than to all these patients.
