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Updated: May 13, 2025

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Associations of serum MANF with severity and prognosis in community-acquired pneumonia patients

Wen-Nan Wang1,2, Xin-Li Zhang1,3, Jian-Feng Xie4

  • 1Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Anhui Medical University, Furong Road No. 678, Hefei, 230601, Anhui, China.

Scientific Reports
|April 13, 2025
PubMed

Insights

Serum MANF levels are elevated in community-acquired pneumonia (CAP) patients and correlate with disease severity. Higher MANF indicates a greater risk of poor prognosis, suggesting its potential as a diagnostic biomarker.

Area of Science:

  • Biochemistry
  • Immunology
  • Pulmonology

Background:

  • Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum stress-induced factor with known protective roles.
  • The association between serum MANF levels and community-acquired pneumonia (CAP) severity and prognosis is not well understood.

Purpose of the Study:

  • To investigate the relationship between serum MANF levels and the severity and prognosis of CAP in adult patients.

Main Methods:

  • A prospective cohort study involving 319 adult CAP patients.
  • Serum MANF levels were quantified using enzyme-linked immunosorbent assay (ELISA).
  • Statistical analyses included multivariate linear and logistic regression.

Main Results:

  • Serum MANF levels were significantly upregulated in CAP patients compared to healthy controls.
  • MANF levels correlated positively with severity scores (CURB-65, PSI, APACHE II, SMART-COP).
  • Elevated MANF was associated with increased need for mechanical ventilation, ICU admission, 30-day mortality, and poor hospitalization outcomes.

Conclusions:

  • Serum MANF expression positively correlates with CAP severity and poor prognosis.
  • MANF shows potential as a valuable diagnostic and prognostic biomarker for CAP patients.
Keywords:
Cohort studyCommunity-acquired pneumoniaMANFPrognosisSeverity

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