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Conserved Binding Sites

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally...

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Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells

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Beyond peptide targeting sequences: machine learning of cellular condensate localization

Jonathon A Ditlev^1,2,3, Julie D Forman-Kay^4,5

¹Molecular Medicine Program, Hospital for Sick Children, Toronto, ON, Canada. jonathon.ditlev@sickkids.ca.

|April 13, 2025

Summary

No abstract available in PubMed .

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