Engineered 3D-Printable Nanohydroxyapatite Biocomposites with Cold Plasma-Tailored Surface Features to Boost...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Polymer Science

Background:

• Medical implants require advanced biomaterials for enhanced clinical performance.
• Synthetic bone graft substitutes, particularly polymer-based options, are under development.
• Limitations exist in traditional implants, driving innovation in material design.

Purpose of the Study:

• To develop versatile nanohydroxyapatite (nHAP) biocomposites for bone substitutes.
• To create materials compatible with resin composite systems and 3D printing.
• To overcome limitations associated with conventional medical implants.

Main Methods:

• Incorporation of nHAP and strontium-doped SiO2 glass particles into a photocurable methacrylate monomer system.
• Application of cold atmospheric plasma irradiation for surface modification.
• Evaluation of mechanical strength, surface hydrophilicity, in vitro osteogenic activity, and in vivo bone integration.

Main Results:

• The developed biocomposite exhibits strong mechanical properties.
• Cold plasma treatment enhanced surface hydrophilicity and exposed nanofillers.
• Demonstrated in vitro osteogenic activity and in vivo bone integration.
• Successful 3D printing of a gyroid lattice structure confirmed printability.

Conclusions:

• The nHAP-biocomposite shows promising biomechanical and biological properties.
• This material has potential for revolutionizing dental, maxillofacial, and orthopedic implant applications.
• The study highlights the versatility and efficacy of the developed biomaterial for bone reconstruction.