Abstract
HLA-DQA1*01:169 differs from HLA-DQA1*01:01:01:09 by one nucleotide substitution in codon 175 in exon 3.
HLA-DQA1*01:169 differs from HLA-DQA1*01:01:01:09 by one nucleotide substitution in codon 175 in exon 3.
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
The Concept of Multiple Allelism
Multiple allelism describes genes that exist in three or more allelic forms. Although diploid organisms, like humans, normally possess only two alleles of each gene, there are multiple alleles of many (if not most) human genes present in a population. Blood type is one example of multiple allelism. There are three alleles for blood type (HBB gene) in humans: IA, IB, and i.
Incomplete Dominance
Sickle cell anemia, which is caused by a mutation in the gene...
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...