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Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study
Zheng Zhang1,2, Yating Wang3, Jiazheng Li3
1Department of Sleep and Psychology, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China.
European Journal of Psychotraumatology
|April 14, 2025
Summary
Childhood maltreatment (CM) is causally linked to increased asthma risk. This Mendelian randomization study confirms CM
Area of Science:
- Genetics
- Epidemiology
- Public Health
Background:
- Previous research suggests a link between childhood maltreatment (CM) and asthma.
- The etiological pathways remain unclear, necessitating further investigation.
Purpose of the Study:
- To investigate the potential causal relationship between childhood maltreatment (CM) and asthma using a Mendelian randomization (MR) approach.
- To assess the association across different asthma phenotypes, including pediatric and adult asthma.
Main Methods:
- Utilized Genome-Wide Association Studies (GWAS) data from the UK Biobank.
- Employed Mendelian randomization (MR) with inverse-variance weighted (IVW), MR-Egger, and MR-PRESSO methods.
- Conducted stratified analyses for pediatric and adult asthma phenotypes.
Main Results:
- Significant causal associations were found between CM and increased risk for asthma (AsthmaUKB, AsthmaIEU), pediatric asthma, and adult asthma.
- Inverse-variance weighted (IVW) analyses showed odds ratios ranging from 1.59 to 1.72.
- MR-Egger and MR-PRESSO tests confirmed the absence of pleiotropy, supporting causal inferences.
Conclusions:
- Childhood maltreatment (CM) is causally associated with an increased risk of developing asthma.
- Findings highlight the importance of addressing CM in asthma prevention and intervention strategies.
- This study provides a foundation for understanding how early-life adversities contribute to asthma etiology.
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