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Related Experiment Video

Updated: May 13, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
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Lesioning Through a Directional Deep Brain Stimulation Lead in the Subthalamic Nucleus.

Alfonso Enrique Martinez Nunez1, Dorian M Kusyk1, Joshua K Wong1

  • 1Norman Fixel Institute for Neurological Disorders, Departments of Neurology and Neurosurgery, University of Florida, Gainesville, FL, US.

Tremor and Other Hyperkinetic Movements (New York, N.Y.)
|April 14, 2025
PubMed
Summary

A novel technique used radiofrequency ablation to create a lesion through an existing deep brain stimulation (DBS) lead, offering a treatment option for Parkinson's disease patients with hardware infections.

Keywords:
Deep Brain StimulationHardware complicationSubthalamic nucleusSubthalamotomy

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Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • Parkinson's disease (PD) is often treated with subthalamic nucleus deep brain stimulation (DBS).
  • Hardware-related infections can necessitate DBS system removal, leading to loss of therapeutic benefit.
  • Patients may face challenges with device removal and subsequent treatment options.

Purpose of the Study:

  • To describe a novel technique for lesioning the subthalamic nucleus using the existing DBS lead.
  • To evaluate the feasibility of creating a targeted subthalamotomy during hardware explantation.
  • To offer an alternative treatment for PD patients with DBS hardware infections.

Main Methods:

  • A 59-year-old woman with a Parkinson's disease DBS system infection underwent hardware explantation.
  • Radiofrequency ablation was applied through the implanted DBS lead to create a multilevel lesion in the subthalamic nucleus.
  • The DBS lead and hardware were subsequently removed.

Main Results:

  • The procedure successfully created a targeted subthalamotomy via the existing DBS lead.
  • The DBS hardware was safely removed after lesioning.
  • This approach provides a therapeutic option for patients with DBS infections.

Conclusions:

  • Lesioning through a DBS lead using radiofrequency ablation is a viable therapeutic option for Parkinson's disease patients with hardware infections.
  • This technique may be suitable for patients who do not desire re-implantation or have a history of recurrent infections.
  • Complexity increases with segmented leads, requiring careful procedural planning.