Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

303
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
303
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

90
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
90

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of self-efficacy and perceived benefits and barriers with sugar-sweetened beverage consumption patterns: a secondary analysis of the 2017-2020 Nutrition and Health Survey in Taiwan (NAHSIT).

Frontiers in nutrition·2026
Same author

Volumetric Imaging of Ex Vivo Oral Mucosa Specimens with Multi-Scale Wide Field-of-View Optical Coherence Tomography/Microscopy in Near-Infrared-II Window.

Diagnostics (Basel, Switzerland)·2026
Same author

Arecoline-induced EV-mediated ZNF582 hypermethylation drives IFIT1-PD-L1 immune evasion in oral squamous cell carcinoma.

Clinical epigenetics·2026
Same author

Physiologic and Lactate Dynamics During Voluntary Breath-Hold: A Systematic Review and Meta-Analysis.

Wilderness & environmental medicine·2026
Same author

Incidence and Site-Specific Risk Factors of Jaw Osteoradionecrosis for Head and Neck Patients in the IMRT/VMAT Era: Evidence From a Large, Hospital-Based Cohort.

Head & neck·2026
Same author

Mediation of Pre-Pregnancy Body Mass Index and Dietary Patterns with Relation to Vitamin D and Erythropoiesis-Related Micronutrients in Pregnant Women.

International journal of medical sciences·2026

Related Experiment Video

Updated: May 13, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K

Sex differences in prognostic factors and genomic variations in oral squamous cell carcinoma: A 5-year retrospective

Hui-Hsin Ko1,2,3,4, Fang-Yu Wu3,5, Ya-Syuan Chen6

  • 1Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.

Journal of Dental Sciences
|April 14, 2025
PubMed
Summary

Oral squamous cell carcinoma (OSCC) shows distinct sex-related prognostic factors and genomic variations. Personalized treatments targeting these differences may improve outcomes, especially for women with OSCC.

Keywords:
BioinformaticsOral squamous cell carcinoma (OSCC)PrognosisSex differencesTumor microenvironmentgenomic variation

More Related Videos

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

982
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

341

Related Experiment Videos

Last Updated: May 13, 2025

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
07:29

Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment

Published on: April 22, 2019

11.4K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

982
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

341

Area of Science:

  • Oncology
  • Genomics
  • Cancer Research

Background:

  • Oral squamous cell carcinoma (OSCC) incidence is rising, particularly in women.
  • Understanding sex-specific prognostic factors and genomic profiles is crucial for effective treatment.

Purpose of the Study:

  • To investigate prognostic factors and genomic variations in oral squamous cell carcinoma (OSCC) between male and female patients.
  • To identify key differences that could inform personalized treatment strategies.

Main Methods:

  • Analysis of 98 OSCC cases treated at National Taiwan University Hospital (2013-2018).
  • Examination of patient cohort, clinical characteristics, and genomic profiles.
  • Comparative analysis of prognostic factors and survival rates between sexes.

Main Results:

  • Female patients showed higher tongue cancer incidence; males had higher buccal cancer rates.
  • Prognostic factors varied by sex, including age, cancer site, alcohol use, betel chewing, and smoking.
  • Genomic analysis revealed distinct gene set alterations and immune cell profiles between sexes, with women showing poorer survival in specific subgroups.
  • Women with tongue OSCC or without oral habits had poorer 5-year survival rates.

Conclusions:

  • Distinct sex-related differences in OSCC prognosis and genomic characteristics exist.
  • Personalized treatment approaches tailored to sex-specific risk factors and genomic profiles are recommended.
  • These targeted strategies hold potential for improving clinical outcomes, especially in female OSCC patients.