Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

473
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
473
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

294
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
294
What is Genetic Engineering?00:49

What is Genetic Engineering?

72.8K
Overview
72.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Use of an AI Image Recognition-Based Smartphone App in Personalized Bowel Preparation Before Colonoscopy: Prospective Randomized Controlled Trial.

JMIR mHealth and uHealth·2026
Same author

Haplotype-resolved methylomes reveal parent-of-origin DNA methylation imbalance in autism spectrum disorder.

Science advances·2026
Same author

A massively parallel reporter assay of <i>MECP2</i> cis-regulatory elements reveals genetic candidates for male-biased autism.

bioRxiv : the preprint server for biology·2026
Same author

Microvascular endothelial scavenger receptor class B type I protects against heart failure with preserved ejection fraction by inhibiting T-cell cardiotropism.

EMBO molecular medicine·2026
Same author

The effectiveness of multimodal prehabilitation on functional capacity and clinical outcomes in patients undergoing elective laparoscopic colorectal cancer surgery: a systematic review of meta-analysis of randomized controlled trials.

Journal of cancer survivorship : research and practice·2026
Same author

Home-based multimodal prehabilitation before colorectal cancer surgery: a systematic review and meta-analysis.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026

Related Experiment Video

Updated: May 13, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.9K

Genetic advances in neurodevelopmental disorders.

Shilin Gao1,2, Chaoyi Shan3, Rong Zhang1,2

  • 1Department of Neuroscience, Neuroscience Research Institute, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.

Medical Review (2021)
|April 14, 2025
PubMed
Summary

Genetic factors significantly contribute to neurodevelopmental disorders (NDDs). Advanced sequencing technologies have identified over 200 high-risk genes, yet many NDD cases remain undiagnosed, highlighting the need for further research.

Keywords:
De novo mutationscommon variationgeneticsneurodevelopmental disordersrare variation

More Related Videos

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.0K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.5K

Related Experiment Videos

Last Updated: May 13, 2025

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

9.9K
A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior
06:59

A Pipeline using Bilateral In Utero Electroporation to Interrogate Genetic Influences on Rodent Behavior

Published on: May 21, 2020

4.0K
A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

8.5K

Area of Science:

  • Genetics
  • Neuroscience
  • Pediatrics

Background:

  • Neurodevelopmental disorders (NDDs) are complex childhood conditions impacting social, cognitive, and emotional development.
  • Genetic factors are crucial in NDD etiology, with over 200 high-risk genes identified.

Purpose of the Study:

  • To review advancements in genetic findings for NDDs.
  • To discuss the genetic architecture models and remaining diagnostic challenges.

Main Methods:

  • Large-scale whole exome sequencing (WES) and whole genome sequencing (WGS).
  • Identification of various variant types: de novo mutations (DNMs), copy number variations (CNVs), rare inherited variants (RIVs), and common variation.

Main Results:

  • Over 200 high-risk NDD genes implicated in synaptic function, transcriptional, and epigenetic regulation have been identified.
  • Monogenic, oligogenic, polygenic, and omnigenic models proposed for NDD genetic architecture.
  • A significant portion of NDD patients still lack a definitive genetic diagnosis.

Conclusions:

  • Despite advances, the genetic basis of NDDs remains incompletely understood.
  • Future research must identify novel risk factors, including noncoding variants and their interplay, to resolve NDD etiology and heterogeneity.