Thromboelastography Reference Values for Third-Trimester Healthy Obstetric Patients in Northern Mexico.

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Clinical Pathology

Background:

• Thromboelastography (TEG) provides comprehensive hemostasis analysis.
• Establishing regional reference values for TEG in pregnancy is crucial for accurate interpretation.
• Third-trimester pregnancy is associated with hemostatic changes.

Purpose of the Study:

• To determine kaolin-based thromboelastography reference values in healthy third-trimester pregnant patients in Northern Mexico.
• To compare these values with existing international reference ranges.
• To identify potential regional variations in coagulation profiles during pregnancy.

Main Methods:

• Prospective, descriptive, cross-sectional study design.
• Inclusion of 280 healthy third-trimester pregnant patients (aged 18-38).
• Kaolin-based TEG analysis using a Haemonetics TEG 5000 system and Hoffman regression for reference value calculation.

Main Results:

• Established reference values for R time (1-7 min), clot kinetics (1-2), angle (59°-82°), maximum amplitude (60-86 mm), and clot lysis (0%-6% at 30 min, 0%-8% at 60 min).
• Significant differences noted compared to European and North American cohorts.
• Observed shorter reaction times, enhanced clot kinetics, larger angles, and higher maximum amplitude in the Mexican cohort.

Conclusions:

• Calculated specific thromboelastography reference values for the Northern Mexico region.
• The Northern Mexico cohort exhibits a distinct coagulation profile characterized by faster clot formation and dynamics.
• No significant differences in enzymatic lysis activity were found compared to other geographic regions.