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Updated: May 13, 2025
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Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
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Current and future advances in practice: arboviral arthritides.
Ashish Sharma1, Vinod Ravindran2,3
1Dilshad Garden, Rheumatology Clinic, New Delhi, India.
Rheumatology Advances in Practice
|April 14, 2025
Summary
Arboviral arthritides, like chikungunya, cause chronic joint pain and inflammation, often mimicking rheumatoid arthritis. Early diagnosis and management are crucial for patients, with a new vaccine offering prevention.
Area of Science:
- Medical Virology
- Rheumatology
- Epidemiology
Background:
- Arboviral arthritides are viral infections impacting the musculoskeletal system, frequently transmitted by mosquitoes.
- Chikungunya, dengue, and Zika viruses are significant causes of human arboviral arthritides.
- Mosquito vectors near human habitats increase epidemiological importance.
Purpose of the Study:
- To review musculoskeletal syndromes associated with arboviral infections.
- To focus on chikungunya virus-related arthritis and its chronic sequelae.
- To offer clinical guidance for managing chikungunya and related musculoskeletal conditions.
Main Methods:
- Literature review of arboviral arthritides, emphasizing chikungunya.
- Analysis of clinical presentations, pathogenesis, and diagnostic challenges.
- Discussion of current management strategies and prognostic factors.
Main Results:
- Chikungunya virus infection can lead to chronic, erosive inflammatory arthritis resembling rheumatoid arthritis.
- Chronic musculoskeletal symptoms may result from viral persistence or autoimmune triggers.
- Diagnosis and management are complex due to diverse presentations and lack of specific antivirals.
Conclusions:
- Chikungunya-related arthritis presents diagnostic and therapeutic challenges.
- Further research is needed to delineate prognostic factors and optimize immunomodulatory treatment.
- A newly approved vaccine offers a preventive measure against chikungunya virus infection.
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