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Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

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Related Experiment Video

Updated: May 13, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

Published on: December 17, 2010

Immune Checkpoint Inhibitor-Mediated Aseptic Meningitis and Hypophysitis.

Pavel Bleik¹, Panisara Fangsaard¹, Nataliya Yuklyaeva¹

¹Department of Internal Medicine, Bassett Medical Center, Cooperstown, New York, USA.

Case Reports in Oncological Medicine

|April 14, 2025

Summary

Immune checkpoint inhibitors (ICIs) offer advanced cancer treatment but can cause immune-related adverse events. This case details aseptic meningitis and hypophysitis in a patient receiving ipilimumab and nivolumab, emphasizing careful monitoring.

Area of Science:

Oncology
Immunology
Neurology

Background:

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy.
ICI treatment can lead to immune-related adverse events (irAEs).

Keywords:

immunotherapy ipilimumab nivolumab oncology renal cell carcinoma

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Last Updated: May 13, 2025

Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis

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Managing irAEs requires careful patient monitoring.