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Hematological parameters and major adverse cardiovascular events: a prospective study in a Chinese population

Hongna Mu1, Xinyue Wang2, Xianghui Zhao1

  • 1The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, P.R. China.

International Journal of Medical Sciences
|April 14, 2025
PubMed

Insights

Hematological parameters like red blood cell count (RBC) and platelet count (PLT) can predict major adverse cardiovascular events (MACEs) in coronary artery disease patients. Elevated RDW-CV and lower BASO% are significant indicators of cardiovascular risk.

Area of Science:

  • Cardiology
  • Hematology
  • Clinical Research

Background:

  • Hematological parameters are easily accessible clinical tests.
  • Emerging evidence suggests their role in cardiovascular risk prediction.
  • Coronary artery disease (CAD) patients require reliable risk stratification tools.

Purpose of the Study:

  • To investigate the association between baseline hematological parameters and major adverse cardiovascular events (MACEs).
  • To identify specific hematological markers predictive of MACEs in Chinese patients with CAD.

Main Methods:

  • Prospective study of 2,970 Chinese patients undergoing coronary angiography.
  • Baseline measurement of hematological and biochemical indicators.
  • Follow-up for MACEs (myocardial infarction, stroke, revascularization, all-cause mortality) over a median of 79 months.
  • Univariate, multivariate Cox regression, and Kaplan-Meier analyses.

Main Results:

  • 474 MACEs occurred during follow-up.
  • Lower RBC, PLT, PCT, LYMPH%, and higher RDW-CV, RDW-SD, MONO%, NEUT% correlated with reduced survival.
  • Elevated RDW-CV (HR 1.292) was a significant risk factor for MACE.
  • Lower BASO% (HR 0.750) showed a protective effect.
  • Significant associations were found for RDW-CV, BASO%, LYMPH%, PLT, and PCT with MACEs, including nonlinear correlations for PLT and PCT.

Conclusions:

  • RDW-CV, BASO%, PLT, PCT, and LYMPH% are significantly associated with MACEs in CAD patients.
  • These hematological parameters may serve as valuable predictors for cardiovascular risk.
  • Accessible hematological markers can enhance risk assessment in coronary artery disease management.

Keywords:
Coronary artery diseaseHematologic parametersMajor adverse cardiovascular events

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