Low-grade appendiceal mucinous neoplasms: a case series

Appendiceal mucinous neoplasms, including low-grade appendiceal mucinous neoplasms (LAMNs), are infrequent but clinically relevant due to their potential progression to pseudomyxoma peritonei. Timely diagnosis and surgical intervention are critical to preventing complications. We present a case series of three middle-aged men with LAMNs, each of whom exhibited right lower quadrant abdominal pain as their primary symptom. Diagnostic imaging in each case revealed features consistent with appendiceal mucoceles. Pathological findings confirmed LAMN, with varying extents of disease. One patient underwent an open appendectomy for LAMN confined to the appendix, while two required right hemicolectomy due to perforation and extra-appendiceal mucin involvement. LAMNs can be managed effectively through early detection and surgical resection. Complete resection with negative margins results in favorable outcomes and low recurrence rates. More aggressive treatments, including cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy, are necessary in cases with peritoneal involvement.