Upregulated PXDNL promotes invasive breast carcinoma progression
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View abstract on PubMed
Summary
This summary is machine-generated.High peroxidase-like (PXDNL) expression in breast cancer is linked to poorer survival and reduced immune cell infiltration. PXDNL may serve as a prognostic biomarker or therapeutic target for invasive breast carcinoma.
Area Of Science
- Oncology
- Immunology
- Genomics
Background
- Invasive breast carcinoma (BRCA) is a significant health concern for women worldwide.
- The role of peroxidase-like (PXDNL) in BRCA progression remains largely undefined, despite its association with poor prognosis in other cancers.
Purpose Of The Study
- To investigate the potential carcinogenic role of PXDNL in invasive breast carcinoma.
- To analyze the correlation of PXDNL expression with prognosis, immune cell infiltration, and related biological pathways in BRCA.
Main Methods
- Utilized bioinformatic analysis of datasets from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and UALCAN.
- Examined PXDNL expression, promoter methylation, immune cell infiltration, immune checkpoint genes, and pathway enrichment.
Main Results
- PXDNL expression was significantly altered in BRCA, correlating with poorer survival across subtypes.
- High PXDNL expression was associated with reduced infiltration of various immune cells, including CD8+ T cells and NK cells.
- PXDNL expression correlated with immune checkpoint genes and modulated key pathways like epithelial-mesenchymal transition and inflammatory signaling.
Conclusions
- Overexpressed PXDNL is linked to unfavorable prognosis and altered immune microenvironment in BRCA.
- PXDNL presents potential as a prognostic biomarker and a therapeutic target for invasive breast carcinoma.
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