Upregulated PXDNL promotes invasive breast carcinoma progression

Area of Science:

• Oncology
• Immunology
• Genomics

Background:

• Invasive breast carcinoma (BRCA) is a significant health concern for women worldwide.
• The role of peroxidase-like (PXDNL) in BRCA progression remains largely undefined, despite its association with poor prognosis in other cancers.

Purpose of the Study:

• To investigate the potential carcinogenic role of PXDNL in invasive breast carcinoma.
• To analyze the correlation of PXDNL expression with prognosis, immune cell infiltration, and related biological pathways in BRCA.

Main Methods:

• Utilized bioinformatic analysis of datasets from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and UALCAN.
• Examined PXDNL expression, promoter methylation, immune cell infiltration, immune checkpoint genes, and pathway enrichment.

Main Results:

• PXDNL expression was significantly altered in BRCA, correlating with poorer survival across subtypes.
• High PXDNL expression was associated with reduced infiltration of various immune cells, including CD8+ T cells and NK cells.
• PXDNL expression correlated with immune checkpoint genes and modulated key pathways like epithelial-mesenchymal transition and inflammatory signaling.

Conclusions:

• Overexpressed PXDNL is linked to unfavorable prognosis and altered immune microenvironment in BRCA.
• PXDNL presents potential as a prognostic biomarker and a therapeutic target for invasive breast carcinoma.