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Comparative analysis of the effects of microscopic vs. neuroendoscopic transsphenoidal surgery on visual and pituitary function and postoperative recurrence factors in patients with pituitary tumors

  • 0Department of Neurosurgery, The First People's Hospital of Xianyang No. 10 Biyuan Road, Qindu District, Xianyang 712000, Shaanxi, China.
American Journal of Translational Research +

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April 14, 2025

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April 14, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Neuroendoscopic transsphenoidal surgery for pituitary tumors offers better visual and pituitary function recovery than microscopic surgery. This approach is recommended for improved patient outcomes and reduced complications.

Area Of Science

  • Neurosurgery
  • Endocrinology
  • Oncology

Background

  • Pituitary tumors require surgical intervention to manage visual deficits, hormonal imbalances, and mass effect.
  • Transsphenoidal surgery is a common approach, with evolving techniques impacting patient outcomes.

Purpose Of The Study

  • To compare microscopic transsphenoidal surgery (MTSS) versus neuroendoscopic transsphenoidal surgery (NETSS) for pituitary tumors.
  • To evaluate effects on visual function, pituitary function, and postoperative recurrence.

Main Methods

  • Retrospective analysis of 164 pituitary tumor patients (March 2020-March 2022).
  • Comparison between NETSS (n=93) and MTSS (n=71) groups.
  • Analysis of clinical data, perioperative indicators, hormone levels, quality of life, olfactory function, and recurrence rates.

Main Results

  • NETSS showed significantly lower intraoperative bleeding, shorter hospital stays, and higher tumor resection rates than MTSS.
  • NETSS resulted in better improvements in vision, headache, and sexual dysfunction, with higher postoperative hormone levels and quality of life scores.
  • While NETSS led to lower olfactory function scores and overall complication rates, recurrence rates were similar between groups. Tumor size, Knosp classification, and Ki-67 index were independent risk factors for recurrence.

Conclusions

  • Neuroendoscopic transsphenoidal surgery is more effective than microscopic transsphenoidal surgery for pituitary tumors.
  • NETSS demonstrates advantages in reducing operative time, improving visual and pituitary function, and enhancing quality of life.
  • NETSS should be promoted in clinical practice for pituitary tumor treatment.

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