Related Experiment Video
Updated: May 13, 2025
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Predictive value of platelet distribution width on organ damage in patients with metabolic syndrome: a retrospective
Jiaxing Li1, Lirong Zhou2, Ben Li2
1Department of Cardiovascular Medicine, Cardiovascular and Cerebrovascular Disease Hospital, General Hospital of Ningxia Medical University Yinchuan, Ningxia, China.
Objectives:
Metabolic syndrome (MS) is a cluster of metabolic disorders characterized by damage to multiple organs. Platelet distribution width (PDW) has been used to assess the progression of several metabolic disorders, including left ventricular hypertrophy (LVH) and diabetic nephropathy (DN). Therefore, this study aimed to evaluate the predictive value of PDW in relation to organ damage in patients with MS.
Methods:
The study included 151 patients with MS and 113 healthy controls. Clinicopathological data, including sex, age, abdominal circumference, blood pressure, and body mass index (BMI), were collected. The predictive potential of PDW was assessed by analyzing its correlation with MS progression, LVH, atherosclerosis, and kidney function.
Results:
The analysis revealed that patients in the MS group had higher levels of BMI, abdominal circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), and fasting plasma glucose (FPG), and lower levels of high-density lipoprotein cholesterol (HDL-C), compared with controls. PDW was positively correlated with BMI, abdominal circumference, SBP, DBP, and FPG, and negatively correlated with HDL-C. FPG, SBP, and HDL-C were identified as independent parameters contributing to changes in PDW. Furthermore, heart function was positively related to PDW levels, while kidney function was negatively related. Logistic regression analysis further demonstrated that PDW was an independent risk factor for LVH, atherosclerosis, and kidney dysfunction.
Conclusions:
PDW could serve as a promising predictive indicator for organ damage associated with the progression of MS.
Related Concept Videos
01:22Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
01:18Structure and Function of Platelets
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...