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Related Experiment Video

Updated: May 13, 2025

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

Papillary Thyroid Carcinoma With 5 Unique Point Mutations and Typical Behavior.

Aditya Chauhan¹, Siddhartha Sen², Khalid Amin²

¹Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.

JCEM Case Reports

|April 14, 2025

Summary

This study reports a rare case of papillary thyroid carcinoma (PTC) with five unique driver mutations. Despite numerous genetic alterations, the tumor exhibited non-aggressive behavior.

Keywords:

BRAF D594N NRAS Q61H PIK3CA G1007R PTEN mutation number papillary thyroid carcinoma

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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Published on: April 17, 2013

Area of Science:

Oncology
Genetics
Molecular Biology

Background:

Papillary thyroid carcinoma (PTC) typically presents with solitary driver mutations.
The impact and frequency of multiple driver mutations in PTC remain underexplored.

Observation:

A 62-year-old female patient with a 2.6-cm classical PTC was analyzed.
Next-generation sequencing identified five novel single nucleotide variants: BRAF D594N, NRAS Q61H, PIK3CA G1007R, and two PTEN variants (R335*, Y225*).

Findings:

This represents the highest number of pathogenic variants reported in a primary PTC resection specimen to date.
The identified mutations were not previously documented in The Cancer Genome Atlas (TCGA) study for PTC.

Implications:

The non-aggressive clinical course suggests that individual mutations may have weaker oncogenic drivers.
This case highlights the complexity of genetic alterations in PTC and their variable impact on tumor behavior.