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Mumps-associated hepatitis: A rare clinical presentation

Mikiyas G Teferi1, Abel K Gulma1, Meron T Akalu2

  • 1School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Idcases
|April 14, 2025
PubMed
Abstract

Insights

Hepatitis is a rare complication of mumps (a viral infection). This case highlights the importance of considering mumps in patients with elevated liver enzymes and parotid swelling for accurate diagnosis and management.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • Mumps virus, an RNA paramyxovirus, primarily targets glandular tissues.
  • While mumps commonly causes parotitis, complications like orchitis, pancreatitis, and meningoencephalitis can occur.
  • Hepatic involvement in mumps is exceptionally rare, particularly in adults, and often underreported.

Observation:

  • A 20-year-old unvaccinated male presented with fever, malaise, bilateral parotid swelling, nausea, and right upper quadrant discomfort.
  • Physical examination revealed tender parotid enlargement, scleral icterus, and bilateral testicular tenderness.
  • Laboratory tests showed significantly elevated liver enzymes, positive mumps virus IgM serology, and exclusion of other common viral hepatitis causes.

Findings:

  • The case demonstrates mumps-associated hepatitis, a rare clinical presentation.
  • Diagnosis required high clinical suspicion due to overlapping symptoms with other viral hepatitis causes.
  • The patient experienced a self-limiting course with conservative management, and liver functions normalized within four weeks.

Implications:

  • This case underscores the need for vigilance regarding atypical mumps presentations, including hepatitis.
  • Healthcare professionals should consider mumps in the differential diagnosis of elevated liver enzymes, especially in unvaccinated individuals with parotitis.
  • Prompt recognition and appropriate management of mumps-associated hepatitis can prevent unnecessary investigations and ensure timely care.
Keywords:
Case reportHepatitisLiver enzymesMumpsViral infection

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