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Updated: Jun 29, 2026
05:39
Non-Intubated Video-Assisted Thoracoscopic Surgery
Published on: May 26, 2023
Nebulized Dexmedetomidine for Postoperative Sore Throat: A Systematic Review and Meta-analysis
Sunaakshi Puri1, Anjishnujit Bandyopadhyay2, Vighnesh Ashok3
1Department of Paediatric Anaesthesia, Post Graduate Institute of Child Health, Noida, India.
Summary
Preoperative nebulized dexmedetomidine effectively reduced postoperative sore throat compared to placebo. However, it showed no significant difference when compared to nebulized ketamine, with low overall evidence quality.
Area of Science:
- Anesthesiology
- Pharmacology
- Critical Care Medicine
Background:
- Postoperative sore throat (POST) is a frequent complication after general anesthesia.
- The efficacy of preoperative nebulized dexmedetomidine in mitigating POST remains uncertain.
Purpose of the Study:
- To evaluate the effectiveness of preoperative nebulized dexmedetomidine versus nebulized ketamine and placebo in reducing the incidence of POST.
Main Methods:
- A systematic review and meta-analysis of randomized controlled trials was conducted.
- Searches were performed across major databases (PubMed, EMBASE, Web of Science, CENTRAL, Google Scholar) up to May 2024.
- Included trials involved adult patients undergoing general anesthesia with tracheal intubation.
Main Results:
- Preoperative nebulized dexmedetomidine did not significantly reduce POST incidence compared to ketamine at 2, 12, and 24 hours.
- Compared to normal saline placebo, dexmedetomidine significantly decreased POST incidence at all measured time points (2, 12, and 24 hours).
- Eight trials with 686 patients were included in the final analysis.
Conclusions:
- Preoperative dexmedetomidine nebulization is superior to normal saline placebo for reducing POST.
- Its efficacy is comparable to nebulized ketamine in preventing POST.
- The overall quality of the evidence supporting these findings is low.
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