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Updated: May 13, 2025
Three-dimensional Optical-resolution Photoacoustic Microscopy
Published on: May 3, 2011
LED-based optoacoustic tomography of mice
Sandeep Kumar Kalva1,2,3, Xiang Liu1,2, Xosé Luís Deán-Ben1,2
1University of Zurich, Institute of Pharmacology and Toxicology, Institute for Biomedical Engineering, Faculty of Medicine, Zurich, Switzerland.
Significance:
Optoacoustic tomography systems commonly employ bulky and expensive solid-state laser sources readily capable of generating dozens of millijoules of optical energy per pulse. Light-emitting diodes (LEDs) may offer a significantly more affordable and compact solution with excellent pulse-to-pulse stability. Yet, the optical design must optimize the energy density delivered to the target, given the relatively low per-pulse energy output of LEDs.
Aim:
We exploit a full-view LED-based optoacoustic tomography (FLOAT) configuration for in vivo imaging of mice.
Approach:
The system features panoramic light illumination delivering 0.48 mJ of total per-pulse energy with an array of 160 LEDs stacked into a cylindrically focused circular ultrasound array transducer.
Results:
We characterize the imaging performance of the FLOAT system in tissue-mimicking phantoms, subsequently demonstrating its ability for in vivo cross-sectional mouse imaging.
Conclusions:
It is anticipated that the compact, low-cost FLOAT imaging system will open up new venues in resource-limited settings for studying large-scale biodynamics such as pharmacokinetics and biodistribution of molecular agents and drugs on a whole-body level.
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